For starting infusion therapy for autoimmune conditions — Crohn’s / IBD (Remicade, Entyvio), MS (Ocrevus, Tysabri), RA / lupus (Rituxan, Benlysta, Saphnelo, Orencia), and similar. The questions are similar across regimens; the answers vary by drug.

About this drug

1. What is the specific drug you’re recommending, and what does it do?
2. Why this one for me rather than alternatives (other biologics, oral medications, steroids)?
3. How does it work for my condition specifically?
4. How quickly should I expect to feel a difference?
5. What measurable outcomes are we aiming for (lab values, symptom scores, scans)?

Schedule and logistics

1. How often will I get infusions, and how long is each?
2. Do I need a port, or will peripheral IV work?
3. What pre-medications will I need on infusion days?
4. Where will my infusions take place — clinic, home, hospital?
5. Is home infusion an option, and is it covered by insurance?

Side effects and reactions

1. What side effects are most common, and how are they managed?
2. What does an infusion reaction look like, and what’s the response?
3. Are there long-term risks I should know about (cancer, infections, immunosuppression)?
4. What signs would mean I should call you sooner rather than later?

Living with infusion therapy

1. Should I get any vaccines before starting? Any I should avoid afterward?
2. Can I work the day of infusion? The day after?
3. Can I travel with the schedule? Plan pregnancy?
4. How long will I be on this drug? Forever, or with a defined endpoint?
5. What if it stops working — what’s next?

Cost and insurance

1. Will my insurance cover this, and what’s the prior authorization process?
2. What’s my out-of-pocket cost per infusion?
3. Is there a patient assistance program from the manufacturer?
4. What’s the plan if insurance changes or denies coverage?